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UFC on Fox 27: Jacaré vs. Brunson 2 was a mixed martial arts event produced by the Ultimate Fighting Championship held on January 27, 2018, at Spectrum Center in Charlotte, North Carolina, United States. A middleweight rematch between former Strikeforce Middleweight Champion Ronaldo Souza and Derek Brunson served as the event headliner. The pairing met previously in August 2012 under the Strikeforce banner with Souza winning the fight via knockout in the first round.